VHIR Annual Report 201

Vall d'Hebron. Institut de Recerca

Systemic diseases

Miquel Vilardell Tarres

Introduction

This group includes the internal medicine and the rheumatology department. From the research point of view the main research areas are focused on the study of the cutaneous and renal manifestations of lupus disease, the antiphospholipid syndrome, progressive systemic sclerosis, Sjögren syndrome, vasculitis, dermato-polymyositis and rheumatoid arthritis. Currently, despite the underlying etiology of those diseases still remains unknown, there has been an improvement in the prognosis and quality of life of those patients,  based in an early diagnosis, the better understanding of the pathology and consequently with the use of more disease-targeted drugs. Our main research interest is to be able to understand better the pathology of those conditions, with the search of new clinical biomarkers and different treatments through the development of own designed clinical trials and participation in the commercial clinical trials to improve the prognosis of the patients

Research lines

  • DNA methylation study in Systemic Lupus Erythematosus (SLE) patients. PI: Eva Balada Prades
  • Urinary biomarkers detection in lupus nephritis. PI: José Ordi Ros
  • Cancer and myositis. Relevance of the anti-p155 antibodies and importance of the screening for cancer by Positron Emission Tomography and Computed Tomography (PET/CT). PI: Albert Selva O’Callaghan
  • Genetic basis of scleroderma. PI: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla
  • Construcción de un Predictor Diagnóstico para las enfermedades Inflamatorias mediadas por mecanismos inmunes (predictor-IMID). PI: Sara Marsal Barril

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Publications

Total: 32

Impact Factor: 129.096

avg. impact factor: 4.034

Selected articles

Diaz-Gallo L, Gourh P, Broen J, Simeon C, Fonollosa V, Ortego-Centeno N, Agarwal S, Vonk M, Coenen M, Riemekasten G, Hunzelmann N, Hesselstrand R, Tan F, Reveille J, Assassi S, Garcia-Hernandez F, Carreira P, Camps M, Fernandez-Nebro A, de la Pena PG, et al.
Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis
Ann Rheum Dis. 2011 Mar;70(3):454-62.
IF: 9.082

Balada E, Castro Marrero J, Pujol AP, Torres Salido MT, Vilardell Tarres M, Ordi Ros J.
Enhanced transcript levels of CD48 in CD4(+) T cells from systemic lupus erythematosus patients
Immunobiology. 2011 Sep;216(9):1034-7.
IF: 4.114

Carmona FD, Serrano A, Rodriguez-Rodriguez , Castaneda S, Miranda-Filloy JA, Morado IC, Narvaez J, Solans R, Sopena B, Mari-Alfonso B, Unzurrunzaga A, Ortego-Centeno N, Blanco R, de Miguel E, Hidalgo-Conde A, Martin J, Gonzalez-Gay MA.
A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis
J Rheumatol. 2011 Dec;38(12):2598-601.
IF: 3.551

Selva-O’Callaghan A, Fernandez-Luque A, Martinez-Gomez X, Labirua-Iturburu A, Vilardell-Tarres M.
Venous thromboembolism in patients with dermatomyositis and polymyositis
Clin Exp Rheumatol. 2011 Sep-Oct;29(5):846-9.
IF: 2.358

Alonso A, Julia A, Beltran A, Vinaixa M, Diaz M, Ibanez L, Correig X, Marsal S.
AStream: An R package for annotating LC/MS metabolomic data
Bioinformatics. 2011 May 1;27(9):1339-40.
IF: 4.877

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Main research projects

PI: Cortes Hernandez, Josefina
Lupus eritematoso discoide: disección por microarray

PI: Marsal Barril, Sara
Proyecto IMID-Inc, “Biobanco IMIDs diferencial permite identificar biomarcadores y nuevas terapias”

PI: Ordi Ros, José
Estudio para evaluar la eficacia y seguridad de la lenalidomida en el tratamiento del lupus eritematoso cutáneo

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Patents

SARA MARSAL.
IN VITRO METHOD AND KIT FOR PROGNOSIS OR PREDICITION OF RESPONSE BY PATIENTS WITH RHEUMATOID ARTHRITIS TO TREATMENT WITH TNF-ALFA FACTOR BLOCKING AGENTS
Application Form No: ES P200802713

SARA MARSAL.
MÉTODO IN VITRO PARA EL PRONOSTICO O LA PREDICCION DE LA RESPUESTA AL TRATAMIENTO CON AGENTES QUE RECONOCEN EL RECEPTOR DE MEMBRANA CD20 DE LINFOCITOS B EN ARTRITIS REUMATOIDE
Application Form No: ES P200930349

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